Ki Dong PARK
Ki Dong Park received his Ph.D. in Pharmaceutics and Pharmaceutical Chemistry at the University of Utah, USA in 1990. After postdoctoral training at CCCD in Utah, he worked as a principal research scientist at Korea Institute of Science and Technology (KIST) from 1991 to 2000. He joined the faculty in the Department of Molecular Science and Technology and Applied Chemistry and Biological Engineering at Ajou University in 2000. He has been working in many national committees as a chair or member. He was the president of the Korean Society for Biomaterials (KSBM) in 2013 and have been honorary president of KSBM. He served as vice presidents of the Korean Industrial and Applied Chemistry Society and the Korean Translational Medical Device Society. He is an elected Fellow of Korean National Academy of Science and Technology (KAST), an elected Fellow of Biomaterials Science and Engineering ((FBSE) of the International Union of Societies of Biomaterials Science and Engineering and an elected Fellow of American Institute of Medical and Biological Engineering (AIMBE). He is serving as a Congress chair of World Biomaterials Congress (WBC2024) held in Korea 2024. He is a regional editor of Journal of Bioactive and Compatible Polymers and editorial board member of many journals including JBMRA.
He has published over 330 scientific publications, possessed 60 patents, and joined many book chapters. He also received many awards including National WOONGBI Medal for his contributions to the academic societies and scientific achievements. His research interests are wide-ranging from implants, controlled drug delivery, tissue regeneration, and biomimetic surface modification.
Abstract
Therapeutic Platforms based on Injectable Hydrogels
Ki Dong Park
Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea,
email: kdp@ajou.ac.kr,
In-situ forming hydrogels have been widely used as injectable and sprayable therapeutic carriers and scaffolds for a wide range of biomedical applications, owing to their extracellular matrix mimicking properties and minimally invasive surgical procedure. Among various cross-linking methods to create in-situ cross-linkable hydrogels, enzymatic cross-linking has attracted significant interest because of its mild reaction conditions, high efficiency, and substrate specificity. In particular, horseradish peroxidase (HRP)-mediated cross-linking of phenol containing polymers in the presence of hydrogen peroxide (H2O2) has been studied as a promising approach because of its ease of handling, high biocompatibility, and tunable gelation and mechanical properties. In our lab, we used HRP-catalyzed hydrogel formation of various natural/synthetic polymers for versatile biomedical applications, such as therapeutic delivery (peptides, proteins, growth factors, genes, virus, stem cells), and stem cell therapy for tissue regenerations. The hydrogel matrices were made of various synthetic and natural polymers, including PEO-PPO copolymers, gelatin, keratin, hyaluronic acid, chitosan and heparin. Also, we developed the enzyme/H2O2-free hydrogel as dynamic and bioactive matrices for both in vitro and in vivo applications. The development of dynamic hydrogel matrices that can stimulate and enhance cellular behaviors of surrounding tissues for facilitating tissue regeneration, is attracting much attention. Particularly, reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) and reactive nitrogen species (RNS) such as nitric oxide (NO), have been indicated as powerful signaling molecules involved in various biological response. we report different strategies to design the injectable and sprayable hydrogels that can precisely control the delivery of H2O2, and NO for various therapeutic applications such as treatment of vascular disorders, bacterial infections, wound healing. as well as excessive ROS-related diseases. The use of ROS-generating hydrogels (H2O2) as the potential bioinks in 3D printing applications will also be discussed.
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