Gultekin GOLLER
Gultekin Goller is a Material Science Professor in the Department of Metallurgical and Material Engineering at the Istanbul Technical University, Turkey. Co-author of 131 scientific articles, 6 book chapters with over 2448 itations reported by WoS (H-index 27) as a date of September 9st, 2024. In addition, he is member of the scientific committee of different meetings, head of the organizing committee for different international conferences, member of the International Editorial Board of some journals, and reviewer for different journals. He is honoured with the “Doctor Honoris Causa” title in material science from Politehnica University of Bucharest in 2022. He is awarded to “Pro Scientia et Innovatio” Honorary Order of Romania Inventory Forum in 2023. His research interests are in the field of metallurgical & material engineering especially ceramic based composite materials, high entropy alloys, biomaterials and refractory materials. His main activities relating to these topics are focused on the spark plasma sintering, plasma coating and materials characterization by X-ray diffraction and electron microscopic techniques.
Abstract
From Conventional Dosage Forms to Sustainable Plant-Based Capsules: Engineering the Future of Pharmaceutical Biomaterials
Gultekin Goller1
1 Istanbul Technical University, Department of Metallurgical and Materials Engineering, 34469 Maslak, Istanbul, Turkey
Pharmaceutical capsule systems are widely used in modern drug formulations because they enable precise dosing, high patient compliance and controlled drug release. With the growing interest in sustainable, plant-based alternatives to traditional gelatin capsules, the use of biomass-derived polymers in capsule technologies has gained significance. In this study, the laboratory-scale production of plant-based capsule systems derived from cellulose obtained from agricultural by-products was investigated with the aim of developing sustainable pharmaceutical dosage forms. Cellulose-derived polymer solutions were prepared, and capsule shells were produced using the dip-coating method. The effects of parameters such as polymer concentration, solution viscosity, dip time, coating thickness and drying temperature on capsule formation were evaluated during the production process. Film integrity, shape stability and shell homogeneity were optimised by applying controlled drying protocols. The resulting prototype capsules were characterised in terms of their physicochemical, structural and thermomechanical properties; the morphology, moisture content, mechanical strength, thermal behaviour and structural integrity of the capsule shell were examined. The findings demonstrate the suitability of biomass-derived cellulose-based polymers for the production of functional capsule shells and suggest that they could provide a sustainable alternative for plant-based capsule technologies.
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